“Developing iPSC-Derived Cardiomyocyte as a Model System for Evaluating Therapeutic Intervention of DMD Cardiomyopathy”
This year the Pilot and Feasibility Seed Grant Program received many excellent quality applications. We are pleased to be able to provide funding to those that are highly relevant to the missions of the P30 and CDMD.
We would like to recognize the following recipients for the 2014 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
PI: M. Carrie Miceli, Ph.D.
Professor, Microbiology, Immunology & Molecular Genetics, UCLA
Co-PIs: Dr. Stanley Nelson, Dr. April Pyle, Dr. Rachelle Crosbie-Watson, Dr. Linda Baum, and Dr. Melissa Spencer
“Stem Cell Approaches for Combination DMD Exon Skipping Therapy”
PI: Karen Reue, Ph.D.
Professor, Human Genetics, UCLA
Co-PI: Andrea Hevener
“Mechanisms of Muscle Metabolism and Autophagy in Muscular Dystrophy and Statin Myopathy”
PI: Rachelle Crosbie-Watson, Ph.D.
Professor, Integrative Biology and Physiology Neurology, UCLA
Co-PI: Dr. Kenneth Roos
“Restoration of Muscle Cell Adhesion to Treat Cardiomyopathy in Muscular Dystrophy”
PI: Brigitte Gomperts, M.D.
Assistant Professor, Pediatric Hematology/Oncology, UCLA
Co-PI: Dr. April Pyle
“Improving Our Understanding of Duchenne Muscular Dystrophy by Modeling the Muscle Cell Niche”
We would like to recognize the following recipients for the 2013 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
Loren Fong, Ph.D.
Professor of Cardiology, David Geffen School of Medicine, UCLA
“A Fresh Strategy for Treating Muscular Dystrophies Caused by Mutations in LMNA”
Nancy Halnon, M.D.
Associate Professor of Pediatrics and Pediatric Cardiology, David Geffen School of Medicine, UCLA
“Evaluating Cardiopulmonary Exercise Testing for Duchenne Muscular Dystrophy”
Leanne Jones, Ph.D.
Associate Professor of Molecular, Cell and Developmental Biology, UCLA
“Directing Mitochondrial Biogenesis to Enhance Stem Cell Maintenance and Transplantation”
Jonathan Wanagat, M.D., Ph.D.
Assistant Professor of Medicine, Division of Geriatrics at UCLA
“Multiplex Protein Quantitation of Single Muscle Fiber Sections”
Holden Wu, Ph.D.
Adjunct Assistant Professor of Radiology at UCLA
“Development and Evaluation of Free-Breathing High-Resolution 3D MRI for Characterization of Fibro-Fatty Replacement of Cardiac Muscle in Patients with Duchenne Muscular Dystrophy”
In 2012, the Pilot and Feasibility Seed Grant Program received many excellent applications of high quality. The Center for Duchenne Muscular Dystrophy at UCLA was able to partner with the P30 Core Center to provide matching funds for applications aligned with the overall mission of the CDMD, thus extending the number of awards funded this year!
We would like to recognize the following recipients for the 2012 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
*Daniel Cruz, M.D., Ph.D.
Assistant Professor of Cardiology, David Geffen School of Medicine, UCLA
“Harnessing the Microenvironment to Instruct Innate Immune Responses in Duchenne Muscular Dystrophy”
*Linda Baum, M.D., Ph.D.
Professor of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA
“Characterization of the Human Skeletal Muscle Cell Glycome and Identification of Glycan-related Functions in Membrane Stabilization and Extracellular Matrix Interactions”
*Gail Thomas, Ph.D.
Research Scientist III of The Heart Institute, Cedars-Sinai Medical Center
“Screening of NO-Donating Compounds to Alleviate Functional Muscle Ischemia in mdx Mice”
*Daniel Ennis, Ph.D.
Assistant Professor of Radiology, UCLA
“Establishment of Quantitative Cardiac Magnetic Resonance Imaging as a Clinical End Point for Evaluating Ventricular Function in Patients with Duchenne Muscular Dystrophy”
Yibin Wang, Ph.D.
Professor of Anesthesiology, Physiology and Medicine, UCLA
“Fox1 Mediated Transcriptome Remodeling in Muscle Development and Diseases”
Ming Guo, M.D., Ph.D.
Associate Professor of Neurology, Molecular and Medical Pharmacology, UCLA
“Mitochondrial DNA Quality Control in Drosophila and Humans”
(* Indicates CDMD supplement)
PI: April Pyle, Ph.D.
UCLA Department of Microbiology, Immunology and Molecular Genetics, UCLA
“Development of iPSC Cells as Pre-Clinical Screening Tools for DMD”
PI: Eileen Fowler, Ph.D.
UCLA Department of Orthopaedic Surgery
“Outcome Measures for Clinical Trials in DMD”
PI: Melissa Spencer, Ph.D.
UCLA Department of Neurology
“Investigation of CaMK signaling in LGMD2A”
Rachelle H. Crosbie, Ph.D., UCLA Department of Integrative Biology and Physiology
Linda G. Baum, M.D., Ph.D., UCLA Department of Pathology and Laboratory Medicine
“Novel Mechanisms to Enhance Utrophin Expression and Muscle Cell Function”
Douglas L. Black, Ph.D.
UCLA Department of Microbiology, Immunology and Molecular Genetics
Howard Hughes Medical Institute
Peter Stoilov, Ph.D.
UCLA Department of Microbiology, Immunology and Molecular Genetics
“Screening of Small Molecules Targeting the Splicing of SMN2 Exon 7 to Identify Lead Compounds for Treatment of Spinal Muscular Atrophy”
Stanley Nelson, M.D.
UCLA Departments of Human Genetics and Psychiatry
“Implementation of Small Molecule High Throughput Screens for Fibrosis Inhibition”
Request for Applications
Please check back in December, 2018 for funding opportunities.
The Center for Duchenne Muscular Dystrophy Pilot and Feasibility Seed Grants
The Pilot & Feasibility (P&F) Program funds studies in the area of muscle or muscular dystrophy research. These seed grants are funded through a partnership between an NIH funded P30 grant, the CDMD and the UCLA CTSI. The P&F awards may be focused on basic, translational or clinical research. The goal of the P&F Program is to encourage research on muscle by young researchers who recently became independent or senior investigators either entering the muscle field for the first time or exploring a completely new direction. This year, two to four new grants will be awarded, each for up to $30,000. Studies that broadly advance any aspect of the mission of the CDMD and those which use at least one P30-funded Core facility (indicated in the budget) will be given priority.
Scientists and clinicians working on skeletal and cardiac muscle function in health and disease are encouraged to become members of the Center. Apply for Membership.
The Application and Judging Process
Pilot and feasibility proposals are solicited annually. The CDMD executive committee will consider the merits of each proposal based on the strength of the hypothesis, the experimental approach, the relevance to muscular dystrophy and the potential that the project will lead to an NIH grant application. Funding will be available in May 2018.
Proposals are for one-year duration.
The maximal dollar amount that will be awarded is $30,000.
P and F projects using at least one core will be given priority, specify use in your budget.