We would like to recognize the following recipients for the 2018 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
PI: Rachelle Crosbie-Watson
Professor, Integrative Biology & Physiology, UCLA
“Sarcospan Modulators to Treat Duchenne/Becker Muscular Dystrophy”
PI: Karen Reue, Ph.D.
Professor, Human Genetics, UCLA
“Statin Drug Therapy for Dysferlinopathy”
PI: Deirdre Scripture-Adams, Ph.D.
Research Biologist, UCLA
“Time of Flight Mass Cytometry Based on Immune Biomarker”
We would like to recognize the following recipients for the 2017 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
PI: Reza Ardehali, M.D., Ph.D.
Associate Professor of Cardiology, UCLA
“The Role of Cardiac Pericytes in the Development and Progression of DMD Cardiomyopathy”
PI: Marino DiFranco, Ph.D.
Adjunct Professor and Research Physiologist, Department of Physiology, UCLA
“Mechanical Assessment of the Efficacy of Gene Therapy Approaches to Restore Function in Dystrophin-Deficient Muscles”
PI: Jonathan Wanagat, M.D., Ph.D.
Assistant Professor of Medicine, Division of Geriatrics, UCLA
“Quantitative Imaging of the Dystrophin-Glycoprotein Complex”
We would like to recognize the following recipients for the 2016 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
PI: Frank Petrigliano, M.D.
Professor of Orthopedic Surgery, UCLA
“Defining the Myogenic Niche for Rotator Cuff Skeletal Muscle Regeneration by Administration of hPSC-pericytes”
PI: Daniel Ennis, Ph.D.
Professor of Radiological Sciences and Bioengineering, UCLA
“Measuring Cardiomyocyte Performance In Vivo with MRI"
PI: Melissa Spencer, Ph.D.
Professor of Neurology, UCLA
“Generation of a Humanized Mouse Model of DMD”
PI: Huan Meng, Ph.D.
Assistant Professor of Medicine, UCLA
“Custom Design of Polyrotaxane Nanocarrier for CRISPR/Cas9 Delivery in DMD”
PI: Stanley F. Nelson, M.D.
Professor of Human Genetics, UCLA
“Assessment of Vacuum Needle Biopsy System for Sampling in Muscle Disease”
We would like to recognize the following recipients for the 2015 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
PI: Shantanu Joshi, Ph.D.
Department of Neurology, UCLA
“Brain Imaging Signatures in Duchenne Muscular Dystrophy and their Correlates with Cognitive Function”
PI: Sandra Loo, Ph.D.
Department of Psychiatry and Biobehavioral Sciences, UCLA
“Behavioral, Cognitive and Neuropsychological Phenotypes in Duchenne Muscular Dystrophy"
PI: Atsushi Nakano, Ph.D., UCLA Molecular
Cellular and Developmental Biology, UCLA
“Developing iPSC-Derived Cardiomyocyte as a Model System for Evaluating Therapeutic Intervention of DMD Cardiomyopathy”
This year the Pilot and Feasibility Seed Grant Program received many excellent quality applications. We are pleased to be able to provide funding to those that are highly relevant to the missions of the P30 and CDMD.
We would like to recognize the following recipients for the 2014 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
PI: M. Carrie Miceli, Ph.D.
Professor, Microbiology, Immunology & Molecular Genetics, UCLA
Co-PIs: Dr. Stanley Nelson, Dr. April Pyle, Dr. Rachelle Crosbie-Watson, Dr. Linda Baum, and Dr. Melissa Spencer
“Stem Cell Approaches for Combination DMD Exon Skipping Therapy”
PI: Karen Reue, Ph.D.
Professor, Human Genetics, UCLA
Co-PI: Andrea Hevener
“Mechanisms of Muscle Metabolism and Autophagy in Muscular Dystrophy and Statin Myopathy”
PI: Rachelle Crosbie-Watson, Ph.D.
Professor, Integrative Biology and Physiology Neurology, UCLA
Co-PI: Dr. Kenneth Roos
“Restoration of Muscle Cell Adhesion to Treat Cardiomyopathy in Muscular Dystrophy”
PI: Brigitte Gomperts, M.D.
Assistant Professor, Pediatric Hematology/Oncology, UCLA
Co-PI: Dr. April Pyle
“Improving Our Understanding of Duchenne Muscular Dystrophy by Modeling the Muscle Cell Niche”
We would like to recognize the following recipients for the 2013 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
Loren Fong, Ph.D.
Professor of Cardiology, David Geffen School of Medicine, UCLA
“A Fresh Strategy for Treating Muscular Dystrophies Caused by Mutations in LMNA”
Nancy Halnon, M.D.
Associate Professor of Pediatrics and Pediatric Cardiology, David Geffen School of Medicine, UCLA
“Evaluating Cardiopulmonary Exercise Testing for Duchenne Muscular Dystrophy”
Leanne Jones, Ph.D.
Associate Professor of Molecular, Cell and Developmental Biology, UCLA
“Directing Mitochondrial Biogenesis to Enhance Stem Cell Maintenance and Transplantation”
Jonathan Wanagat, M.D., Ph.D.
Assistant Professor of Medicine, Division of Geriatrics at UCLA
“Multiplex Protein Quantitation of Single Muscle Fiber Sections”
Holden Wu, Ph.D.
Adjunct Assistant Professor of Radiology at UCLA
“Development and Evaluation of Free-Breathing High-Resolution 3D MRI for Characterization of Fibro-Fatty Replacement of Cardiac Muscle in Patients with Duchenne Muscular Dystrophy”
In 2012, the Pilot and Feasibility Seed Grant Program received many excellent applications of high quality. The Center for Duchenne Muscular Dystrophy at UCLA was able to partner with the P30 Core Center to provide matching funds for applications aligned with the overall mission of the CDMD, thus extending the number of awards funded this year!
We would like to recognize the following recipients for the 2012 Pilot and Feasibility Seed Grant Award. Congratulations, we look forward to seeing your exciting studies progress!
*Daniel Cruz, M.D., Ph.D.
Assistant Professor of Cardiology, David Geffen School of Medicine, UCLA
“Harnessing the Microenvironment to Instruct Innate Immune Responses in Duchenne Muscular Dystrophy”
*Linda Baum, M.D., Ph.D.
Professor of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA
“Characterization of the Human Skeletal Muscle Cell Glycome and Identification of Glycan-related Functions in Membrane Stabilization and Extracellular Matrix Interactions”
*Gail Thomas, Ph.D.
Research Scientist III of The Heart Institute, Cedars-Sinai Medical Center
“Screening of NO-Donating Compounds to Alleviate Functional Muscle Ischemia in mdx Mice”
*Daniel Ennis, Ph.D.
Assistant Professor of Radiology, UCLA
“Establishment of Quantitative Cardiac Magnetic Resonance Imaging as a Clinical End Point for Evaluating Ventricular Function in Patients with Duchenne Muscular Dystrophy”
Yibin Wang, Ph.D.
Professor of Anesthesiology, Physiology and Medicine, UCLA
“Fox1 Mediated Transcriptome Remodeling in Muscle Development and Diseases”
Ming Guo, M.D., Ph.D.
Associate Professor of Neurology, Molecular and Medical Pharmacology, UCLA
“Mitochondrial DNA Quality Control in Drosophila and Humans”
(* Indicates CDMD supplement)
The Pilot & Feasibility (P&F) Program funds studies in the area of muscle or muscular dystrophy research. These seed grants are funded through a partnership between an NIH funded P30 grant, the CDMD and the UCLA CTSI. The P&F awards may be focused on basic, translational or clinical research. The goal of the P&F Program is to encourage research on muscle by young researchers who recently became independent or senior investigators either entering the muscle field for the first time or exploring a completely new direction. This year, two to four new grants will be awarded, each for up to $30,000. Studies that broadly advance any aspect of the mission of the CDMD and those which use at least one P30-funded Core facility (indicated in the budget) will be given priority.
Eligibility
Scientists and clinicians working on skeletal and cardiac muscle function in health and disease are encouraged to become members of the Center. Apply for Membership.
The Application and Judging Process
Pilot and feasibility proposals are solicited annually. The CDMD executive committee will consider the merits of each proposal based on the strength of the hypothesis, the experimental approach, the relevance to muscular dystrophy and the potential that the project will lead to an NIH grant application. Funding will be available in May 2018.
Award Details
The Cores of the Center Learn about the cores
A complete application in NIH format must include the following:
Conditions of Award
